I installed Vista on my work PC recently and was annoyed to find that my PDA didn’t want to sync. It seems that activesync has been killed off in Vista and replaced with Windows Mobile Device Center. This would be fine, but the version that ships with Vista seems to do bugger all and would only let me sync media files. Which is useless as I hate Windows Media Player.
Anyway, after more googling today it seems you need an update from Microsoft (which they’ve only just released) to actually get it working. I installed that today and I’m syncing properly again!